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Science Behind Our Ingredients

We’ve handpicked every single ingredient to maximise the health benefits of our products

Ashwagandha

Found in night capsule / 380 mg

Known to reduce stress, improve sleep and elevate mood.

  • Ashwagandha contains many compounds that function as antioxidants, protecting your body from oxidative stress. [1,2]
  • Ashwagandha reduces feelings of stress by altering the behaviour of neurons and reducing the concentration of cortisol, a primary stress neurotransmitter. [3,4]
  • Ashwagandha provides relief from the symptoms of severe depression. [4,5]
  • Taking ashwagandha results in a calmer night, with fewer interruptions to sleep, thanks to a compound within it known as triethylene glycol. [6,7]
  • The immune system is boosted by ashwagandha, helping to fight off infections. [8,9]
  • Memory improvements have been demonstrated in studies with ashwagandha supplements. [10,11]
  • Cognitive ability and control over psychomotor functions is improved by ashwagandha intake. [12,13]

Valerian Root

Found in night capsule / 100 mg

The root of the valerian plant is a well known home remedy for sleep, with many people advocating for its ability to improve the quality of sleep. Chemicals in the plant exhibit a sedative effect on the brain and nervous system, damping down overactivity

  • Valerian root contains sedative compounds that promote sleep. [14,15]
  • The valerenic acid present in valerian root has the effect of reducing anxiety. [16,17]
  • Valerian root is known to lessen the intensity of hot flushes that occur during menopause. [18,19]

Griffonia Seeds

Found in night capsule / 20 mg

The West African plant, Griffonia, produces seeds that contain a compound known as 5-hydroxytryptophan (5-HTP). This molecule is the main source of the beneficial effects associated with medicines created using this plant’s components.

  • 5-HTP raises serotonin levels in the brain, improving the quality of sleep and lessening the impact of mood disorders such as anxiety and depression. [20,21]
  • Griffonia is able to make headaches and migraines less intense and less frequent. [22,23]
  • Griffonia protects your cells from damage through its antioxidant characteristics. [24]

Black Pepper

Found in night capsule / 5 mg

Black pepper extracts and powder contain piperine as one of their main active ingredients. It is able to enhance absorption of other plant hormones, so its addition makes the formulation even more potent.

  • Nutrient absorption is facilitated by black pepper, allowing more efficient uptake of minerals such as calcium and selenium, as well as beneficial plant hormones. [25,26]
  • Black pepper improves memory and cognition, staving off neurodegenerative diseases such as Alzheimer’s and Parkinson’s [27,28]
  • The anti-inflammatory effect of black pepper improves overall wellbeing, reducing risk factors for numerous diseases. [29,30]
  • Cholesterol levels are reduced by taking black pepper, aiding weight loss and maintaining a healthy heart. [31,32]

Lion’s Mane

Found in day capsule / 240 mg

Evidence suggests that lion’s mane has a protective effect on the central nervous system and the neurons that comprise it.

  • Lion’s mane is useful for reducing the impact of depression and anxiety, especially when these conditions are linked to chronic inflammation. [33,34]
  • Lion’s mane is able to speed up the repair of damaged nerves, which is particularly applicable to Alzheimer’s patients. [35,36]
  • Lion’s mane also has a preventative role in reducing general damage to the nervous system in the first place. [37,38]
  • Components of lion’s mane function as anti-inflammatory and antioxidant agents, keeping the cells of the body safe from harm. [39,40]
  • Immunity is enhanced by taking lion’s mane, especially the defences in the digestive tract. [41,42]

Guarana

Found in day capsule / 150 mg

Guarana has formed part of tribal Amazonian therapies for thousands of years. It has a greater concentration of caffeine than coffee beans.

  • Guarana contains high levels of caffeine, which provides mental energy and helps focus. [43,44]
  • Memory is improved by taking guarana extract. [45,46]
  • Guarana inhibits the formation of blood clots, reducing the risk of heart disease and other cardiovascular complications. [47,48]
  • The presence of caffeine means that guarana upregulates metabolism, burning more calories and inhibiting the formation of adipose tissue. These qualities are useful for losing weight. [49,50]
  • The antioxidant effects of guarana are most noticeable in preventing skin damage, allowing it to be used as an anti-ageing ingredient. [51,52]

Chaga

Found in day capsule / 30 mg

Chaga in the body results in documented improvements to wellbeing, affecting various systems, such as the immune system, cardiovascular system and metabolism.

  • Chaga directly fights against pathogenic microbes and also improves long-term immune system health by reducing inflammation. [53,54]
  • Cholesterol is reduced by chaga, working against cardiovascular disease and promoting weight loss. [55,56]
  • Chaga contains antioxidants that will reduce the oxidative stress being placed on cells and tissues in your body. [57,58]
  • Blood sugar levels can be lowered by taking chaga, making it useful for those who need to manage glucose homeostasis. [57,58]
  • Chaga exhibits the ability to fight cancer, stopping tumour growth. [59,60]

Cordyceps

Found in day capsule / 30 mg

Cordyceps has been in use in traditional Chinese medicine for many years, where it is believed to free up more chemical energy for use by the body, help maintain youthful features and facilitate both the immune system and the nervous system.

  • Cordyceps makes more energy available by increasing production of ATP, the energy transfer molecule used by our bodies. [61,62]
  • Cordyceps has been shown to reduce fatigue, build strength and enhance libido, particularly in elderly users. [63,64]
  • The antioxidant compounds in cordyceps enable it to be used in anti-ageing formulations. [65,66]
  • By inhibiting key proteins in the signal cascade, cordyceps acts as an anti-inflammatory substance. [67,68]
  • Neuron health is improved by consumption of cordyceps, resulting in better memory and cognitive functioning. This lessens the impact of damage to the brain, such as from head injuries or progressive disease. [69,70]

Maitake

Found in day capsule / 30 mg

Maitake has also been called the dancing mushroom. It appears to have a pronounced protective role, fighting against oxidative stress and mobilising the immune system against pathogens.

  • The action of the immune system is enhanced by maitake, which activates important cells and modulates inflammatory signals. [71,72]
  • Maitake reduces the oxidative stress inflicted on the body through its antioxidative characteristics. [73,72]
  • Maitake produces lower cholesterol levels, promoting health of the heart and circulatory system and combating weight gain. [74,75]

Oyster mushroom

Found in day capsule / 30 mg

Oyster Mushrooms have shown promising indications that it may have some ability to improve the condition of the heart and reduce chronic inflammation.

  • Oyster mushrooms contain numerous important minerals and vitamins, as well as a lot of fibre. They are also low in carbohydrates, which make them a good option for certain restrictive diets. [76,77]
  • The antioxidants contained in oyster mushrooms reduce cellular damage throughout the body. [78,79]
  • Oyster mushrooms promote heart health by lessening heart disease risk factors such as high cholesterol levels and hypertension. [80,81]
  • Numerous anti-inflammatory compounds are present in oyster mushrooms. [82,83]
  • Infections and allergies are addressed by oyster mushroom consumption due to its ability to modulate the immune system. [84,85]

Reishi

Found in day capsule / 30 mg

Reishi has been used in East Asian medicine to protect important organs, such as the lungs, liver and heart.

  • The hepatoprotective properties of reishi improve the health of liver tissue via antioxidant effects. [86,87]
  • Wellbeing is improved by reishi’s anti-inflammatory effect, especially in cases of respiratory conditions such as asthma [88,89]
  • Reishi reduces the occurrence of atherosclerosis, protect the cardiovascular system. [90,91]
  • Reishi can help with stomach ulcers by speeding up the healing process. [92,93]

Shaggy Mane

Found in day capsule / 30 mg

Shaggy Mane’s ability to act as an antioxidant has been investigated in research, as well as its potential to regulate blood glucose levels.

  • Shaggy mane reduces oxidative damage done to cells through its anti-oxidative effect. [94,95]
  • Blood glucose concentrations can be regulated by consumption of shaggy mane extract, keeping them in the desired range. [96,97]

Shiitake

Found in day capsule / 30 mg

Shiitake is packed with helpful vitamins (D & B), along with anti-inflammatory compounds. Shiitake may also have properties that allow it to improve the body’s response to infections.

  • Shiitake mushrooms contain fibre, B vitamins and minerals, as well as being low in calories. This makes them a good choice for a healthy diet. [98,99]
  • The potent anti-inflammatory effect of shiitake can reduce discomfort and promote wellness. [100,101]
  • Shiitake contains multiple compounds that lower cholesterol, improving the health of the heart and decreasing the risk of high blood pressure. [102,103]
  • Shiitake has a direct antimicrobial effect, working against microbes that attempt to infect the body. [104,105]
  • Supplements of shiitake also result in improved immune system health and functioning. [100,106]

      References

  1. Anti-oxidant and free radical scavenging activity of ashwaghanda (Withania somnifera L.) leaves
  2. Antioxidant activity and apoptotic induction as mechanisms of action of Withania somnifera (Ashwagandha) against a hepatocellular carcinoma cell line
  3. A double-blind, placebo-controlled evaluation of the anxiolytic efficacy ff an ethanolic extract of withania somnifera
  4. A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults – 
  5. Effects of a standardized extract of Withania somnifera (Ashwagandha) on depression and anxiety symptoms in persons with schizophrenia participating in a randomized, placebo-controlled clinical trial 
  6. Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction 
  7. Efficacy and Tolerability of Ashwagandha Root Extract in the Elderly for Improvement of General Well-being and Sleep: A Prospective, Randomized, Double-blind, Placebo-controlled Study 
  8. In vivo effects of Ashwagandha (Withania somnifera) extract on the activation of lymphocytes 
  9. In vivo enhancement of natural killer cell activity through tea fortified with Ayurvedic herbs
  10. Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions
  11. Sominone enhances neurite outgrowth and spatial memory mediated by the neurotrophic factor receptor, RET
  12. Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants
  13. A systematic review of the clinical use of Withania somnifera (Ashwagandha) to ameliorate cognitive dysfunction
  14. Valerian Root in Treating Sleep Problems and Associated Disorders—A Systematic Review and Meta-Analysis
  15. Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis
  16. Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress
  17. The anxiolytic effects of a Valerian extract is based on Valerenic acid
  18. The effect of Valerian on the severity and frequency of hot flashes: A triple-blind randomized clinical trial 
  19. The Effects of Valerian Root on Hot Flashes in Menopausal Women
  20. Anxiolytic-like effect of Griffonia simplicifolia Baill. seed extract in rats
  21. L-5-Hydroxytryptophan treatment of sleep terrors in children
  22. A Combination of Tanacetum parthenium, Griffonia simplicifolia and Magnesium (Aurastop®) as Symptomatic Acute Treatment for Migraine Aura: A Retrospective Cohort Study
  23. Nutraceutical preparations in childhood migraine prophylaxis: effects on headache outcomes including disability and behaviour 
  24. 5-HTP (5-Hydroxy-L-tryptophan) Content and Antioxidant Capacities of Wild Griffonia simplicifolia Seed Populations from Ghana and Liberia
  25. Quantum Chemical and Docking Insights into Bioavailability Enhancement of Curcumin by Piperine in Pepper
  26. Black pepper and health claims: a comprehensive treatise
  27. Preventive role of Indian black pepper in animal models of Alzheimer’s disease
  28. Methanolic extract of Piper nigrum fruits improves memory impairment by decreasing brain oxidative stress in amyloid beta(1-42) rat model of Alzheimer’s disease
  29. Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1beta-stimulated fibroblast-like synoviocytes and in rat arthritis models
  30. Piperine inhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma model
  31. Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: results of a randomized controlled trial
  32. Effects of Piper nigrum extracts: Restorative perspectives of high-fat diet-induced changes on lipid profile, body composition, and hormones in Sprague-Dawley rats
  33. Hericium erinaceus Extract Reduces Anxiety and Depressive Behaviors by Promoting Hippocampal Neurogenesis in the Adult Mouse Brain
  34. Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice
  35. The influence of Hericium erinaceus extract on myelination process in vitro
  36. Lion’s Mane, Hericium erinaceus and Tiger Milk, Lignosus rhinocerotis (Higher Basidiomycetes) Medicinal Mushrooms Stimulate Neurite Outgrowth in Dissociated Cells of Brain, Spinal Cord, and Retina: An In Vitro Study 
  37. Effect of an exo-polysaccharide from the culture broth of Hericium erinaceus on enhancement of growth and differentiation of rat adrenal nerve cells
  38. Neuroregenerative potential of lion’s mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury (review) 
  39. Protective Effects of Hericium erinaceus Mycelium and Its Isolated Erinacine A against Ischemia-Injury-Induced Neuronal Cell Death via the Inhibition of iNOS/p38 MAPK and Nitrotyrosine
  40. Hericium erinaceus: an edible mushroom with medicinal values
  41. Immunomodulatory effects of Hericium erinaceus derived polysaccharides are mediated by intestinal immunology 
  42. Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion’s Mane) mushroom: A review 
  43. Improved cognitive performance and mental fatigue following a multi-vitamin and mineral supplement with added guaraná (Paullinia cupana)
  44. Guarana (Paullinia cupana) presents a safe and effective anti-fatigue profile in patients with chronic kidney disease: A randomized, double-blind, three-arm, controlled clinical trial
  45. Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: comparison and interaction with Panax ginseng
  46. Guarana (Paullinia cupana) ameliorates memory impairment and modulates acetylcholinesterase activity in Poloxamer-407-induced hyperlipidemia in rat brain
  47. Studies on the nature of anti-platelet aggregatory factors in the seeds of the Amazonian Herb Guarana (Paullinia cupana) 
  48. Guaraná (Paullinia cupana Kunth) effects on LDL oxidation in elderly people: an in vitro and in vivo study 
  49. Effects of yerba maté, a plant extract formulation (“YGD”) and resveratrol in 3T3-L1 adipogenesis
  50. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial
  51. Anti-Aging and Antioxidant Potential of Paullinia cupana var. sorbilis: Findings in Caenorhabditis elegans Indicate a New Utilization for Roasted Seeds of Guarana
  52. Caffeine’s mechanisms of action and its cosmetic use
  53. Inonotus obliquus extracts suppress antigen-specific IgE production through the modulation of Th1/Th2 cytokines in ovalbumin-sensitized mice
  54. Antiviral activity of aqueous extracts of the birch fungus Inonotus obliquus on the human immunodeficiency virus
  55. Anti-diabetic effects of Inonotus obliquus polysaccharides in streptozotocin-induced type 2 diabetic mice and potential mechanism via PI3K-Akt signal pathway
  56. Antioxidant effect of Inonotus obliquus
  57. Anti-diabetic effects of Inonotus obliquus polysaccharides-chromium (III) complex in type 2 diabetic mice and its sub-acute toxicity evaluation in normal mice
  58. Phytochemical characteristics and hypoglycaemic activity of fraction from mushroom Inonotus obliquus 
  59. Antitumor and immunomodulatory activity of water-soluble polysaccharide from Inonotus obliquus 
  60. Antitumor activity of water extract of a mushroom, Inonotus obliquus, against HT-29 human colon cancer cells
  61. SUPPLEMENTAL ANTI-FATIGUE EFFECTS OF CORDYCEPS SINENSIS (TOCHU-KASO) EXTRACT POWDER DURING THREE STEPWISE EXERCISE OF HUMAN 
  62. Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming
  63. Antiaging effect of Cordyceps sinensis extract
  64. Evaluation of anti-fatigue property of the extruded product of cereal grains mixed with Cordyceps militaris on mice 
  65. Antioxidant and anti-aging activities of polysaccharides from Cordyceps cicadae 
  66. Protective Effects on Mitochondria and Anti-Aging Activity of Polysaccharides from Cultivated Fruiting Bodies of Cordyceps militaris
  67. Anti-inflammation and antioxidant effect of Cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis, in middle cerebral artery occlusion-induced focal cerebral ischemia in rats
  68. Regulation of human cytokines by Cordyceps militaris
  69. Mycelial Extract of Cordyceps ophioglossoides Prevents Neuronal Cell Death and Ameliorates b-Amyloid Peptide-Induced Memory Deficits in Rats
  70. Cordyceps cicadae NTTU 868 Mycelium with The Addition of Bioavailable Forms of Magnesium from Deep Ocean Water Prevents the Aβ40 and Streptozotocin-Induced Memory Deficit via Suppressing Alzheimer’s Disease Risk Factors and Increasing Magnesium Uptake of Brain
  71. Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts
  72. Antioxidant and immunomodulatory effects of a α-glucan from fruit body of maitake (Grifola frondosa)
  73. Antioxidant Properties and Antioxidant Compounds of Various Extracts from the Edible Basidiomycete Grifola Frondosa (Maitake) 
  74. Effect of Dietary Maitake (Grifola frondosa) Mushrooms on Plasma Cholesterol and Hepatic Gene Expression in Cholesterol-Fed Mice 
  75. Grifola frondosa (Maitake) extract activates PPARδ and improves glucose intolerance in high-fat diet-induced obese mice 
  76. Mushrooms, oyster, raw 
  77. Nutritional impact of adding a serving of mushrooms on usual intakes and nutrient adequacy using National Health and Nutrition Examination Survey 2011–2016 data
  78. Antioxidant Activities and Tyrosinase Inhibitory Effects of Different Extracts from Pleurotus ostreatus Fruiting Bodies
  79. Oyster mushroom: A rich source of antioxidants
  80. Antihypercholesterolemic and antioxidative effects of an extract of the oyster mushroom, Pleurotus ostreatus, and its major constituent, chrysin, in Triton WR-1339-induced hypercholesterolemic rats
  81. Lipid lowering effects of oyster mushroom (Pleurotus ostreatus) in humans
  82. β-Glucan-based cream (containing pleuran isolated from pleurotus ostreatus) in supportive treatment of mild-to-moderate atopic dermatitis
  83. Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-κB and AP-1 signaling
  84. Immunomodulatory effect of pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections
  85. Anti-allergic effect of Pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections
  86. Ameliorative effect of Ganoderma lucidum on carbon tetrachloride-induced liver fibrosis in rats
  87. Hepatoprotective effects of Ganoderma lucidum peptides against d-galactosamine-induced liver injury in mice
  88. Triterpenoids from Ganoderma lucidum and Their Potential Anti-inflammatory Effects
  89. Ganoderma formosanum polysaccharides attenuate Th2 inflammation and airway hyperresponsiveness in a murine model of allergic asthma
  90. Ganoderma lucidum triterpenoids and polysaccharides attenuate atherosclerotic plaque in high-fat diet rabbits 
  91. The role of polysaccharide peptide of Ganoderma lucidum as a potent antioxidant against atherosclerosis in high risk and stable angina patients 
  92. Ganoderma lucidum Polysaccharide Fractions Accelerate Healing of Acetic Acid-Induced Ulcers in Rats
  93. Ganoderma Lucidum Pharmacopuncture for Teating Ethanol-induced Chronic Gastric Ulcers in Rats
  94. Anti-Oxidative Activity of An Aqueous Suspension of Commercial Preparation of The Mushroom Coprinus comatus 
  95. Antioxidant and hepatoprotective activities of modified polysaccharides from Coprinus comatus in mice with alcohol-induced liver injury
  96. Comparative study on the monosaccharide compositions, antioxidant and hypoglycemic activities in vitro of intracellular and extracellular polysaccharides of liquid fermented Coprinus comatus 
  97. Characterization and anti-diabetic nephropathic ability of mycelium polysaccharides from Coprinus comatus
  98. Mushrooms, shiitake, dried
  99. A Review on General Nutritional Compounds and Pharmacological Properties of the Lentinula edodes Mushroom
  100. Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults
  101. Extracts from Lentinula edodes (Shiitake) Edible Mushrooms Enriched with Vitamin D Exert an Anti-Inflammatory Hepatoprotective Effect
  102. Edible mushrooms: Role in the prevention of cardiovascular diseases
  103. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats
  104. An examination of antibacterial and antifungal properties of constituents of Shiitake (Lentinula edodes) and Oyster (Pleurotus ostreatus) mushrooms
  105. Antimicrobial and antitumor activities of chitosan from shiitake stipes, compared to commercial chitosan from crab shells
  106. The shiitake mushroom-derived immuno-stimulant lentinan protects against murine malaria blood-stage infection by evoking adaptive immune-responses